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Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on "Protein Kinases" related pathways that threaten human health and life. As "Protein Kinases" are related to many health problems, clinicians, basic science researchers and students need this information. Chapter "Signal Transduction in Immune Cells and Protein Kinases" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

History of human medicine --- farmacologie

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This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.

History of human medicine --- farmacologie

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Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.

History of human medicine --- farmacologie

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This book reproduces and comments John Woodall’s handbook which was used as standard text for medical treatment at sea in the seventeenth century and was the first instruction for medical service aboard on the whole. In 1612 the East India Company, founded in London 1600 and invested with special royal privileges and authority, appointed John Woodall as its first surgeon-general, who had gained great medical experience at theatres of war abroad. Woodall was appointed the task to radically reform the medical aid on sailing ships and to supervise the education of talented ship doctors. He was the first one to establish standardized regulations concerning the provision of instruments and medicaments on board. To this end he wrote an instructive manual for ship surgeons with the title “The Surgions Mate”, published in 1617 in London and edited repeatedly until 1655, listing essential instruments and remedies for the use at sea and providing detailed annotations. The manual’s particularities include notes on the portion of paracelsian drugs, the first enema of tobacco, the treatment of gunshot wounds and the strong recommendation of lemon juice against scurvy. Moreover, descriptions of injuries, instruments, and many diseases as a result of Woodall’s extended personal observations at sea are given. The present edition of this exceptional classic includes comprehensive annotations on the first medical chest and its application on sailing ships. Also, the implications of Woodall’s achievements in regard to the development of ship medicine and pharmacy in other seafaring nations are discussed. The book will appeal to historians of medicine and interested readers alike.

History of human medicine --- geneeskunde --- geschiedenis

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This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .

History of human medicine --- Pharmacology. Therapy --- farmacologie